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The angiogenic response of aortic rings from CD11bDTR transgenic mice is markedly impaired following treatment with diphtheria toxin. The number of microvessels in these cultures is reduced by 94% compared to untreated controls. Angiogenesis in cultures of non-transgenic aortic rings is unaffected by the diphtheria toxin treatment. *** = P < 0.001; n = 5.
