Table 3.
Odds ratios (OR) and 95% confidence intervals (CI) for the associations between hormonal contraception and oncogenic HPV DNA positivity.
Negative (n=107)* | Positive (n=151)* | |||
---|---|---|---|---|
Contraceptive Type | n (%) | n (%) | ORadj† | 95% CI |
DMPA | ||||
Recent user‡ | 17 (16) | 32 (21) | 1.6 | 0.7, 3.7 |
≥1 years of use | 5 (5) | 20 (13) | 4.7 | 1.4, 15.8 |
<1 years of use | 12 (11) | 12 (8) | 0.7 | 0.3, 2.1 |
Former user | 12 (11) | 21 (14) | 1.5 | 0., 3.6 |
Never user | 77 (73) | 98 (65) | 1.0 | |
COC | ||||
Recent user‡ | 66 (62) | 87 (58) | 0.6 | 0.3, 1.5 |
≥1 years of use | 32 (30) | 48 (32) | 0.8 | 0.3, 2.0 |
<1 years of use | 34 (32) | 39 (26) | 0.5 | 0.2, 1.2 |
Former user | 23 (22) | 33 (22) | 0.9 | 0.3, 2.3 |
Never user | 17 (16) | 31 (20) | 1.0 |
One woman in the negative histology group was excluded from the analysis because of missing information on lifetime number of male partners.
Adjusted for age at colposcopy-biopsy (18–19, 20–24, 25–29, 30–50), lifetime number of male partners (1, 2–4, 5–14, ≥15), and parity (0, 1, ≥2).
Recent use was defined as using that method within six months of the colposcopy-biopsy visit. The most recent COC brand reported was Ortho tri-cyclen (39%) followed by Ortho cyclen (19%) and Ortho-novum 7/7/7 (11%); 4% could not recall the brand of combined oral contraceptive the most recently used.