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. 2009 May 7;330(2):423–429. doi: 10.1124/jpet.109.153551

Fig. 2.

Fig. 2.

Net uptake and efflux of mitoxantrone in MDA-MB-435 cells in the nuclei of the cells (A) and in the cytoplasm of the cells (B). Accumulation of mitoxantrone in the nuclei and cytoplasm of MDA-MB-435 cells at the end of uptake perfusion (C) and at the end of efflux perfusion (D). Fluorescent intensity (accumulation) of mitoxantrone in intracellular nuclei and cytoplasm at the end of uptake and efflux perfusion was calculated relative to that in the same cellular compartment at the baseline level and at the end of uptake perfusion, respectively.