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Effects of cumulative doses of cocaine in separate groups of rats treated with saline (saline), 3.0 mg/kg spiradoline (3.0 SPR), and 10 mg/kg spiradoline (10 SPR). Left, locomotor activity expressed as a percentage of saline control values. Right, AUC estimates for each group. Vertical lines represent the S.E.; where not indicated, the S.E. fell within the data point.
