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. 2009 Apr 29;330(2):476–486. doi: 10.1124/jpet.108.150037

Fig. 7.

Fig. 7.

Top, effects of cumulative doses of cocaine in separate groups of rats treated with saline (saline), 10 mg/kg morphine (10 MOR; redrawn from Fig. 5), 10 mg/kg morphine + 10 mg/kg spiradoline (10 MOR + 10 SPR), and 10 mg/kg morphine + 10 mg/kg spiradoline + 10 mg/kg nor-binaltorphimine (10 MOR + 10 SPR + 10 NBNI). Bottom, effects of cumulative doses of cocaine in separate groups of rats treated with saline (saline), 1.0 mg/kg buprenorphine (1.0 BUP; redrawn from Fig. 5), 1.0 mg/kg buprenorphine + 10 mg/kg spiradoline (1.0 BUP + 10 SPR), and 1.0 mg/kg buprenorphine + 10 mg/kg spiradoline + 10 mg/kg nor-binaltorphimine (1.0 BUP + 10 SPR + 10 NBNI). Left, locomotor activity expressed as a percentage of saline control values. Right, AUC estimates for each group. Horizontal lines, significant differences between groups (p < 0.05). Vertical lines, S.E.; where not indicated, the S.E. fell within the data point. Significant differences are indicated as follows: a, significantly different from saline control group (p < 0.05); and b, significantly different from spiradoline-treated group (p < 0.05).