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. 2009 May 12;330(2):541–549. doi: 10.1124/jpet.109.153171

Fig. 8.

Fig. 8.

Nicotine-induced changes in pCREB are mediated by β2, but not α7, nAChRs. A, increase in pCREB after acute nicotine treatment in the VTA and NAc is observed in WT mice. This increase is not observed in β2 nAChR KO mice. B, increase in pCREB after acute nicotine treatment in the VTA and NAc is observed in WT and α7 nAChR KO mice. The y-axis represents the ratio of pCREB/α-tubulin. Each point represents the mean ± S.E.M. of six to eight mice. *, p < 0.05 from corresponding saline group. Amy, amygdala; Hippo, hippocampus; nic, nicotine; sal, saline; α-tub, α-tubulin.