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The mean (± S.D.) DIG dose-normalized plasma concentration-time profile in M. nemestrina is not significantly different AP (n = 4, ○) from that obtained PP (n = 4, •) after either intra-arterial (10 μg/kg) (A) or oral (100 μg/kg) (B) administration of the drug. For intra-arterial study, only three pregnant macaques were studied (AP, n = 3).
