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No significant difference in MDZ depletion was observed AP (n = 6) and PP (n = 6) in hepatic (A) or proximal small-intestinal S-9 fractions (B; n = 4, AP or PP). This depletion was inhibited by 0.5 μM KTZ in both tissues (A and B). The percentage of MDZ remaining was compared with control incubations in the absence of inhibitor at 0 min.
