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A, no significant difference in 1′-OH MDZ formation was observed in hepatic S-9 fractions obtained AP (n = 6) and PP (n = 6). B, formation of 1′-OH MDZ was inhibited by 0.5 μM KTZ, 0.5 mM ERY, and 0.1 mM TAO in hepatic S-9 fractions and expressed CYP3A64 enzyme.
