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. Author manuscript; available in PMC: 2010 Jan 15.
Published in final edited form as: Neuron. 2009 Jan 15;61(1):71–84. doi: 10.1016/j.neuron.2008.11.015

Figure 7. Treatment with TTX significantly increases mEPSC amplitudes in neurons transfected with β-catenin* without affecting their dendritic morphology.

Figure 7

(A) Representative images of neurons transfected with GFP alone, with GFP + β-cat* and with GFP +β-cat* and treated with TTX. (B) Graph showing TDBL in neurons transfected with GFP (2054.64 ± 133.21 μm), β-cat* (2580.87 ± 141.98 μm, p = 0.01), β-cat* + TTX (2728.74 ± 195.81 μm, p < 0.01 vs GFP, p = 0.55 vs β-cat*). (C) Representative mEPSC recordings and average mEPSC waveforms for each condition; the scale bars are 20 pA and 500 msec and 5 pA and 10 ms respectively. (D) Average mEPSC amplitudes from neurons transfected or treated with GFP (12.64 ± 0.47 pA), TTX (14.63 ± 0.60 pA, p = 0.01), TTX + K+ (14.41 ± 0.60 pA, p < 0.05 vs GFP, p = 0.79 vs TTX), or TTX + β-cat* (14.79 ± 0.79 pA, p < 0.05 vs GFP, p = 0.88 vs TTX). (E – G) Cumulative distributions of mEPSC amplitudes, each manipulation (dark gray) plotted against GFP (light gray). (C) TTX vs GFP, p < 0.01. (D) TTX + K+ vs GFP, p = 0.01. (E) TTX + β-cat* vs GFP, p <0.005. *p < 0.05, **p<0.001, error bars represent SEM.