Table 3. Sound eye visual acuity at the outcome exam.
| Trial 1 | Trial 2 | |||
|---|---|---|---|---|
| 18-week exam | 17-week exam | |||
| Atropine only N = 24 |
Atropine + plano N = 31 |
Atropine only N = 20 |
Patching 2 hrs/day N = 13 |
|
| Change from baseline,* n (%) | ||||
| ≥2 lines worse | 1 (4) | 4 (13) | 1 (5) | 0 |
| 1 line worse | 0 | 2 (6) | 2 (10) | 1 (8) |
| 0 | 11 (46) | 13 (42) | 11 (55) | 8 (62) |
| 1 line better | 9 (38) | 12 (39) | 4 (20) | 4 (31) |
| ≥2 lines better | 3 (13) | 0 | 2 (10) | 0 |
| Mean (SD) lines change | 0.5 (0.9) | 0.1 (1.0) | 0.2 (1.0) | 0.2 (0.6) |
| Distribution of visual acuity, n (%) | ||||
| 20/63 | 0 | 1 (3) | 0 | 0 |
| 20/50 | 1 (4) | 3 (10) | 0 | 0 |
| 20/40 | 1 (4) | 4 (13) | 1 (5) | 0 |
| 20/32 | 6 (25) | 7 (23) | 1 (5) | 0 |
| 20/25 | 8 (33) | 7 (23) | 2 (10) | 1 (8) |
| 20/20 | 6 (25) | 7 (23) | 4 (20) | 4 (31) |
| 20/16 | 2 (8) | 2 (6) | 11 (55) | 5 (38) |
| 20/12 | — | — | 1 (5) | 3 (23) |
| Mean (SD) logMAR | 0.10 (0.12) | 0.15 (0.15) | −0.03 (0.13) | −0.07 (0.10) |
| Snellen equivalent | 20/25 | 20/32-2 | 20/20-2 | 20/25+1 |
*
For Trial 2, change from baseline in logMAR rounded to nearest line for presentation.
Trial 1: weekend atropine with spectacle correction as clinically indicated compared with weekend atropine plus a plano lens for the sound eye in children 3 to 6 years of age.
Trial 2: weekend atropine compared with patching 2 hours per day to the sound eye for children 7 to 12 years of age.