TABLE 1.

Potency of d-amphetamine, l-amphetamine, d-methamphetamine, and MDMA (EC₅₀ in micromolar) at TAAR1 receptors in heterologous cellular systems

Studies and Receptors Studied	EC50
	d-Amphetamine	l-Amphetamine	d-Methamphetamine	MDMA
		μM
Bunzow et al. (2001); Reese et al. (2007)
mTAAR1	0.21	4.96	0.92
rTAAR1	0.81	0.29	0.89	1.700[(±)-MDMA]
h-rTAAR1	1.12	3.09	4.44
Wolinsky et al. (2006)
mTAAR1	0.002	0.065	0.070
Miller et al. (2005); Xie and Miller (2007); Xie et al. (2007)
rhTAAR1	0.682	1.700	0.320
Wainscott et al. (2007)
rTAAR1	1.210	1.400
hTAAR1	0.994	1.720
Lewin et al. (2008)
hTAAR1	0.935	0.920
Barak et al. (2008)
hTAAR1	0.136	0.245	1.31	0.370[(+)-MDMA]

mTAAR1, mouse TAAR1; rTAAR1, rat TAAR1; rhTAAR1, rhesus monkey TAAR1; h-rTAAR1, chimeric human-rat TAAR1; hTAAR1, human TAAR1