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. 2009 Apr 30;76(2):356–368. doi: 10.1124/mol.109.056531

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Fig. 9. — VU0255035 blocks the CCh-induced potentiation of NMDAR currents in CA1 pyramidal cells. A, representative traces of NMDA-evoked currents obtained from a typical experiment (top) and time course of normalized amplitude of NMDAR currents before, during and after application of 10 μM CCh (n = 9) (bottom). B, representative traces of NMDAR currents (top) and time course of normalized amplitude of NMDAR currents in control, during application of VU0255035 (5 μM) and application of VU0255035 with 10 μM CCh, and washout (n = 7) (bottom), showing the ability of VU0255035 to block CCh-induced potentiation of NMDAR currents. C, summary of the peak potentiation of NMDAR currents by 10 μM CCh in control (n = 9) and in the presence of VU0255035 (n = 7) (p = 0.016). Data represent mean ± S.E.M.