Regulation of apoptosis pathway gene expression in cultured neurons (A) or astrocytes (B) exposed to cell phone RF/MW radiation. Cells were placed proximate to a cell phone for 2 hrs, as shown in Fig. 1, then analyzed for mRNA expression by real time RT-PCR. mRNA levels are shown relative to expression of 18S mRNA. (A) Neurons show upregulation of Asc, caspase-2, and caspase-6 gene expression after exposure to a cell phone either in the “on” mode (exposed) or “stand-by” mode (sham exposed) versus non-exposed, control cells (*p<0.05). Caspase-9 and Bax mRNA levels are unchanged. (B) Astrocytes show upregulated expression of Asc, caspase-2, caspase-6 and Bax genes after exposure to a cell phone in the “on” mode (exposed) but not in the “stand-by” mode (sham exposed) versus non-exposed, control cells (*p<0.05; #p<0.01). Caspase-9 gene expression was unchanged. For both (A) and (B), values are the mean ± SEM (n=3).