Skip to main content
. Author manuscript; available in PMC: 2009 Jul 20.
Published in final edited form as: Ann Biomed Eng. 2008 Dec 9;37(2):363–374. doi: 10.1007/s10439-008-9613-x

FIGURE 3.

FIGURE 3

Computer simulation of neuron polarization on substrates with experimentally relevant feature sizes. (a) Shows the predicted probability of polarization for E18 hippocampal neurons cultured on a PDMS substrate containing topography (Top) vs. that predicted for those cells cultured on a substrate containing immobilized nerve growth factor (NGF). The figure shows the entire range of topographical features investigated (1–100 μm) in this simulation for four characteristic lengths of interest (10, 17.7, 50, 110 μm). (b) Demonstrates the same plot as in (a) at a smaller x-axis scale for direct comparison with experiments performed.