Table 1.
Parameter values for ATM and p53 module
| ATM module | p53-MDM2 module |
| k1 = 1 min-1 | katm' = 0.01 s-1 |
| k2 = 0.01 μM | kmd' = 0.03 min-1 |
| k3 = 0.005 min-1 | δp53 = 0.01 min-1 |
| k4 = 2.5 min-1 | δMDM2 = 0.002 min-1 |
| k5 = 1 | Ka = 0.3 μM |
| k6 = 0.1 min-1 | Kb = 0.3 μM |
| k7 = 0.5 μM | Kc = 0.3 μM |
| k8 = 1 min-1 | Kd = 0.5 μM |
| k9 = 0.01 μM | Ke = 0.5 μM |
| k10 = 0.005 min-1 | kind = 0.02 μM·min-1 |
| k11 = 0.8 μM·min-1 | ktrans = 0.1 μM·min-1 |
| k12 = 0.1 μM | μp53 = 0.003 μM·min-1 |
| k13 = 0.02 μM-1·min-1 | μMDM2 = 0.002 μM·min-1 |
| [ATM]total = 1 μM | m = 4 |
| [MRN]total = 1 μM | n = 3 np = 3 |