Table 2.
Clinical characteristics of the main group (separated in men and women), total cases and controls
| Men n = 41 |
Women n = 39 |
P | Total cases n = 80 |
Controls n = 11 |
p* | |
| Age (years) | 33.5(11.5) | 55.0(11.0) | < 0.01 | 43.0(24.0) | 54.0(31.0) | 0.03 |
| BMI (kg/m2) | 24.7(3.5) | 24.3(4.5) | 0.25 | 24.4(4.0) | 25.6(2.0) | 0.09 |
| Waist (cm) | 93.0(14.0) | 78.5(13.0) | < 0.01 | 85.0(17.0) | 93.0(26.5) | 0.26 |
| TC (mg/dl) | 292.0(70.5) | 319.0(45.0) | 0.01 | 313.5(56.3) | 215.0(39.0) | < 0.01 |
| TG0 (mg/dl) | 110.0(90.5) | 99.0(83.0) | 0.53 | 105.5(85.0) | 68.0(33.0) | < 0.01 |
| TG2 (mg/dl) | 206.0(129.3) | 158.0(131.8) | 0.20 | 174.0(119.0) | 108.0(53.8) | < 0.01 |
| TG4 (mg/dl) | 245.0(162.5) | 195.0(142.5) | 0.12 | 220.0(160.5) | 134.0(52.0) | < 0.01 |
| TG6 (mg/dl) | 203.0(166.5) | 165.0(136.0) | 0.40 | 173.0(171.0) | 140.0(63.0) | 0.01 |
| TG8 (mg/dl) | 157.0(105.0) | 134.0(111.0) | 0.77 | 139.5(107.0) | 87.0(68.0) | 0.02 |
| TG AUC (mg/dl/h) | 1568.1(1225.7) | 1360.6(809.0) | 0.16 | 1407.9(995.5) | 920.8(436.0) | < 0.01 |
| TG i-AUC (mg/dl/h) | 604.6(630.8) | 521.9(420.2) | 0.08 | 564.5(483.8) | 346.5(131.7) | 0.03 |
| HDL (mg/dl) | 40.0(14.5) | 55.0(23.0) | < 0.01 | 48.0(18.5) | 47.0(12.0) | 0.26 |
| LDL (mg/dl) | 231.0(61.0) | 238.0(45.0) | 0.17 | 232.0(58.8) | 135.0(29.0) | < 0.01 |
| Apo AI (mg/dl) | 132.0(29.3) | 158.4(32.0) | < 0.01 | 145.5(40.7) | 144.0(31.8) | 0.22 |
| Apo B (mg/dl) | 153.0(32.5) | 162.5(34.1) | 0.27 | 156.9(35.0) | 101.0(19.5) | < 0.01 |
| Lp (a) (mg/dl) | 16.0(15.1) | 15.9(30.5) | 0.23 | 16.0(20.3) | 21.5(31.4) | 0.69 |
| Glu (mg/dl) | 86.0(14.3) | 90.0(17.0) | 0.27 | 87.5(15.0) | 81.5(12.8) | 0.03 |
| TaqIB allele frequency n (%) | ||||||
| B1 | 43 (52.4) | 45 (57.7) | 0.50 | 88 (55.0) | 7 (35.0) | 0.08 |
| B2 | 39 (47.6) | 33 (42.3) | 72 (45.0) | 13 (65.0) | ||
| I405V allele frequency n (%) | ||||||
| I | 54 (65.9) | 50 (64.1) | 0.82 | 104 (65.0) | 16 (72.7) | 0.43 |
| V | 28 (34.1) | 28 (35.9) | 56 (35.0) | 6 (27.3) | ||
| S447X allele frequency n (%) | ||||||
| S | 75 (91.5) | 69 (88.5) | 0.53 | 144 (90.0) | 18 (81.8) | 0.26 |
| X | 7 (8.5) | 9 (11.5) | 16 (10.0) | 4 (18.2) |
Data are presented as medians (interquartile ranges). BMI: body mass index, TC: total cholesterol, TG: triglycerides, AUC: area under the curve, i-AUC: incremental AUC, HDL: high density lipoprotein cholesterol, LDL: low density lipoprotein cholesterol, Apo A: apolipoprotein A, Apo B: apolipoprotein B, Lp (a): lipoprotein (a), Glu: glucose, hFH: heterozygotes for familial hypercholesterolaemia.
*: All comparisons between cases and controls are age-adjusted.