Table 4.
Clinical and metabolic characteristics of the hFH-N men and women (subgroup hFH-N).
| hFH-N men n = 17 |
hFH-N women n = 18 |
p | |
| Age (years) | 33.0(13.5) | 55.5(13.8) | < 0.01 |
| BMI (kg/m2) | 24.5(2.9) | 22.8(4.1) | < 0.01 |
| Waist (cm) | 91.0(13.0) | 76.0(13.0) | < 0.01 |
| TC (mg/dl) | 292.0(64.0) | 331.0(59.3) | 0.08 |
| TG0 (mg/dl) | 76.0(30.5) | 76.0(38.8) | 0.91 |
| TG2 (mg/dl) | 128.5(24.8) | 112.0(54.5) | 0.25 |
| TG4 (mg/dl) | 145.5(63.5) | 132.0(78.5) | 0.21 |
| TG6 (mg/dl) | 131.0(60.5) | 126.0(64.3) | 0.96 |
| TG8 (mg/dl) | 103.0(57.5) | 99.5(66.8) | 0.46 |
| TG AUC (mg/dl/h) | 990.3(335.0) | 874.0(351.6) | 0.37 |
| TG i-AUC (mg/dl/h) | 377.3(161.5) | 312.8(235.8) | 0.17 |
| HDL (mg/dl) | 48.0(18.5) | 60.0(24.0) | 0.02 |
| LDL (mg/dl) | 232.0(66.5) | 254.5(58.0) | 0.26 |
| Apo AI (mg/dl) | 137.5(41.7) | 158.4(45.8) | 0.09 |
| Apo B (mg/dl) | 146.8(41.0) | 158.5(40.1) | 0.26 |
| Lp (a) (mg/dl) | 16.0(18.5) | 18.4(28.8) | 0.65 |
| Glu (mg/dl) | 82.0(11.5) | 89.0(12.5) | 0.35 |
| TaqIB allele frequency, n (%) | |||
| B1 | 17 (50.0) | 20 (55.6) | 0.64 |
| B2 | 17 (50.0) | 16 (44.4) | |
| I405V allele frequency, n (%) | |||
| I | 21 (61.8) | 22 (61.1) | 0.96 |
| V | 13 (38.2) | 14 (38.9) | |
| S447X allele frequency, n (%) | |||
| S | 31 (91.2) | 31 (86.1) | 0.51 |
| X | 3 (8.8) | 5 (13.9) |
Data are presented as medians (interquartile ranges). BMI: body mass index, TC: total cholesterol, TG: triglycerides, AUC: area under the curve, i-AUC: incremental AUC, HDL: high density lipoprotein cholesterol, LDL: low density lipoprotein cholesterol, Apo A: apolipoprotein AI, Apo B: apolipoprotein B, Lp (a): lipoprotein (a), Glu: glucose.