Figure 1. IL-17 production is augmented in brain abscesses of TLR2 KO mice out to 3 weeks post-infection.

TLR2 KO and WT mice (n = 4 to 6 per group) were infected with S. aureus intracerebrally as described in the Materials and Methods. Animals were euthanized at 7, 14, or 21 days following bacterial exposure, whereupon IL-17 expression was quantitated by ELISA. Results were normalized based on the amount of total protein recovered from abscesses to correct for differences in tissue sampling size. Significant differences in IL-17 expression between brain abscesses TLR2 KO and WT mice are indicated by asterisks (* p < 0.05). Results are representative of two independent experiments.