Figure 10. IL-17F production is transiently elevated in brain abscesses of TLR2 KO mice.

TLR2 KO and WT mice (n = 3 to 5 per group) were infected with S. aureus intracerebrally as described in the Materials and Methods. Animals were euthanized at the indicated time points following bacterial exposure, whereupon IL-17F expression was quantitated by ELISA. Results were normalized based on the amount of total protein recovered from abscesses to correct for differences in tissue sampling size. Significant differences in IL-17F expression between brain abscesses TLR2 KO and WT mice are indicated by asterisks (* p < 0.05). Results are representative of two independent experiments.