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Ultrastructural feature of age-associated neuronal mitochondrial change in ApoE4 mice. Mitochondria-derived lysosome associated with lipofuscin appears to be the main feature of mitochondrial damage. Asterisk: normal mitochondria. Arrowhead: mitochondria-derived lysosomes. Double Arrowhead: hypoxic mitochondria. Magnification: A and B) 20,000; C) 25,000; D) 15,000. Abbreviations used in figures: N-Neuronal Nucleus.
