Fig 1.

Sonication of the skin. (a) Sonication was carried out by applying a hand piece containing ultrasound coupling medium to the subject’s volar forearm skin. A reference sensor clasped in the subject’s hand helped determine the duration of sonication by interacting with the main control console. Photographs of a representative sonicated skin site are shown (b) immediately prior to sonication, (c) immediately after sonication and (d) 24 h after sonication. No erythema, edema or adverse events were associated with sonication at any time. Only a transient skin indentation due to application of the hand piece was observed immediately after sonication (c).