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. Author manuscript; available in PMC: 2010 Jun 2.
Published in final edited form as: Biochemistry. 2009 Jun 2;48(21):4476–4487. doi: 10.1021/bi8023509

Figure 10.

Figure 10

Chemical structures of mithramycin (MTM) analogues mithramycin SK (MTM SK)(40), mithramycin SDK (MtmSDK)(20) and 3D-demycarosyl-3D-digitoxosyl-mithramycin (Demyc-Dig-MTM)(41), all generated by combinatorial biosynthesis, which have increased efficacy compared with MTM. The structural differences compared with MTM are highlighted in blue.