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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Glia. 2009 Sep;57(12):1316–1325. doi: 10.1002/glia.20851

Figure 4. rhMMP-9 stimulates biphasic ERK1/2 activation in myelinating Schwann cells.

Figure 4

Schwann cell differentiation was induced with dbcAMP (500 μM) for 48 h, followed by treatment with rhMMP-9 (100 nM) for 15 min. A, rhMMP-9 stimulates transient ERK1/2 activation over a 1 h period. Successful Schwann cell differentiation was confirmed by myelin protein zero (P0) expression, β-actin was used as loading control. B, An extended time-course of rhMMP-9 stimulation displayed biphasic activation of ERK1/2, as seen in undifferentiated cells in Fig. 3.