Figure 7. Enhancement of burst firing requires PLC activation, release of Ca²⁺ from internal stores, and an increase in intracellular Ca²⁺ concentration.

Layout is as described for Fig. 2.

A. Representative (left) and group (right; n=8) data from experiments in which TBS was given in the presence of a PLC inhibitor (U-73122, 25 μM). B. Representative (left) and group (right) data from experiments in which the internal recording solution contained the Ca²⁺-ATPase inhibitor thapsigargin (2 μM). In the group data, red circles indicate experiments in which TBS was given (n=6). Group data are also shown for experiments in which no TBS was given (right, black squares; n=6). C. Representative (left) and group (right) data from experiments in which the internal recording solution contained the Ca²⁺ chelator (BAPTA, 10 mM). In the group data, red circles indicate experiments in which TBS was given (n=5). Group data are also shown for experiments in which no TBS was given (right, black squares; n=5).