Figure 3.

Dose-dependent inhibition of proteasomal activity. Fluorogenic assays were used to assess chymotrypsin-like (chy-like) activity. Cultures with Epx exposure exhibited lower proteasome activity than their vehicle-treated counterparts, and the extent of reduction depended on the drug concentration. The chy-like activity of the Epx-treated (at 2 nM) was 70% of that found with its vehicle control verifying proteasomal inhibition of such drug exposure (p <0.05, Student's t test; n=3). Y axis showed fluorescence intensity in arbitrary units.