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Flow chart for clonality testing for suspected T-cell proliferations. Both TCRG and TCRB gene rearrangements are analyzed simultaneously because of complementarity of the targets and, as such, increase the clonality detection rate. For tissues showing fragmented DNA, testing the TCRG-gene target is most useful and reliable because of the lower-length amplicon sizes. Assessment of TCRB is not recommended in the case of severe fragmentation of DNA samples
