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Superposition of all five drug complexes in crystal structures. (A) Active sites of CA II complexes. (B) Active sites of CA IX mimic complexes. AZM (red), BZM (magenta), CHL (green), EZM (orange), MZM (blue), Zn2+ (black sphere). (C) and (D) Superposition of all five drugs in CA II and CA IX mimic respectively. (E) and (F) Superposition of all five drugs in CA II and CA IX mimic respectively rotated 90 degrees from previous view. Figure generated in PyMOL (43).
