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. 2000 Sep 19;97(20):10984–10989. doi: 10.1073/pnas.190167297

Figure 1.

Figure 1

Schematic representation of the experimental strategy and expression of the constructs. (A) Scheme used to compare the proliferative effect of MLL-ELL to MLL-ENL and to mutants in vitro and to study its leukemic effect in vivo. IRES, internal ribosomal entry site; PGK, phosphoglycerate kinase. (B) Western blot analysis of MLL-ELL and ELL expressed from the MSCV construct in transfected Bosc23 cells by using an anti-ELL antiserum. The arrowheads indicate the specific bands. The MLL-ELL fusion protein migrates at approximately 250 kDa and the ELL protein migrates at approximately 75 kDa. The position of molecular mass markers is shown.