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Ablation of the ATPB site fails to eliminate the enhancing effects of ATP on InsP3R1. A stable cell line was generated expressing InsP3R1-ΔATPB (G2016A, G2018A, and G2021A). A shows representative ER Ca2+ measurements from permeabilized DT40-InsP3R1-ΔATPB cells treated with 10 μm InsP3 in the absence or presence of 10 μm InsP3. B shows the mean ± S.E. for each condition from five separate experiments (*, p ≤ .05; Student's unpaired t test).
