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. 2009 Apr 21;284(24):16135–16145. doi: 10.1074/jbc.M109.007484

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Knockdown of OTUB1 in Ishikawa endometrial cancer cells increases transcription of PR gene and placental alkaline phosphatase activity. Ishikawa cells were transfected with ON TARGET SMART POOL siOTUB1 or adequate siRNA control pool (Dharmacon). A, successful knockdown of OTUB1 protein and OTUB1 mRNA. B, knockdown of OTUB1 increases E2-dependent transcription of PR mRNA. The right panel indicates increase in estrogen-dependent PR mRNA fold induction. C, knockdown of OTUB1 does not increase E2-dependent production of GREB1 mRNA. D, knockdown of OTUB1 increases E2-dependent placental alkaline phosphatase activity.