FIGURE 5.

69-loop adopts a unique conformation. A, sequence alignment between human pro-G1B and pro-G1B from porcine and bovine, color-coded as following: blue for identical alignment, red shading for semi-conserved substitution, and other colors for no similarity. The alignment was performed using BIOEDIT (49). B, superposition of all published pancreatic PLA2 in the 69-loop region. Pro-hG1B is colored in red, pro-pG1B (PDB code: 1HN4) is colored in blue, others (porcine and bovine G1B) are colored in green. Tyr69 is presented as a stick model.