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. 2009 Apr 21;284(24):16256–16263. doi: 10.1074/jbc.M109.009647

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Compound 3289-8625 penetrates the cell membrane and blocks Wnt signaling in Xenopus. A, the siamois reporter construct and synthetic mRNAs corresponding to Wnt3A (1 pg) and β-catenin (100 pg) were injected into the animal-pole region of two-cell stage Xenopus embryos, and ectodermal explants were dissected at late blastula stage for a luciferase assay. B, an embryo that received an injection of Wnt3A mRNA (1 pg) developed a complete secondary axis. C, an embryo that received injections of Wnt3A mRNA (1 pg) and was treated with compound 3289-8625 (10 μm) developed a partial secondary axis. D, summary of the effect of compound 3289-8625 on the formation of the secondary axis induced by Wnt3A. All results are the mean value from three independent experiments.