FIGURE 6.

Inhibition of the GABA-coupled current, the Li⁺-induced leak current, and the Na⁺-dependent transient current with SKF89976A. A, normalized dose-response curves for the GABA-coupled currents at −70 mV (I_GABA, squares), the Li⁺-induced leak current at −150 mV (I_Li, down triangles), and the Q_max values obtained from transient current data (Q_GAT, circles) plotted as function of the SKF89976A concentration. These relationships were fitted to give the following IC_{50(SKF89976A)} values for I_GABA, 4.3 ± 1.0 μm (n = 5); for I_Li, 152 ± 23 μm (n = 6); and for the transient currents, 0.24 ± 0.11 μm (n = 3).