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Nanoflow ESI-TOF mass spectra of PKG that was irradiated in the presence of the photolabel W64-[Phe(Tmd)-12] for 10 min at 366 nm in the absence of cGMP (A) and the presence of 100 μm cGMP (B). Shown are on the left are the m/z spectra containing the charge state envelope of dimeric PKG, and shown are on the right are the corresponding deconvoluted mass spectra. These spectra clearly indicate that cGMP activation is a prerequisite for the binding of peptides substrates.
