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. 2009 Apr 15;284(24):16354–16368. doi: 10.1074/jbc.M808521200

TABLE 1.

Inhibition contants (KI) of PKA- or PKG-specific peptide inhibitors and the PKA/PKG specificity index

Peptide Sequence PKGKi PKAKi Specificity index (PKA/PKG) Ref.
μm μm
PKI(5–24) TTYDFIASGRTGRRNAIHD-NH2 150 0.003 0.0002 (11)
WW21 TQAKRKKALAMA-NH2 7.5 750 100 (11)
W45 LRKKKKKH 0.82 ± 0.33 559 680 (17)
DT-6 YGRGGRRQRRRPP 1.1 ± 0.22 26 ± 4 23.6 (17)
DT-2 YGRKKRRQRRRPPLRKKKKKH 0.0125 ± 0.003 16.5 ± 3.8 1320 (17)