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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Pharmacol Ther. 2008 Aug 15;120(2):102–128. doi: 10.1016/j.pharmthera.2008.07.006

Fig. 12.

Fig. 12

Total self-administered intake during a 24 h cocaine binge in intermittently defeated and non-defeated rats that were “pharmacologically protected” with infusions of the NMDA receptor antagonist AP-5 into the VTA prior to each stress episode. The mean (±SEM) total amount of cocaine (mg/kg) self-administered during the 24-hour bringe is shown for non-stressed (open bar) and episodically defeated (filled bars) rats. The open and dark gray bars represent rats that were infused with artificial cerebrospinal fluid (aCSF) and the light gray bar represents rats that were infused with the NMDA receptor antagonist AP-5 (5 nmol). (From Covington et al., 2008).