Skip to main content
. Author manuscript; available in PMC: 2009 Jul 21.
Published in final edited form as: Nat Chem Biol. 2008 Nov 16;5(1):26–28. doi: 10.1038/nchembio.128

Figure 1. Cytochrome P450-based approach for selective fluorination of organic molecules.

Figure 1

(a) Hydroxyl groups are introduced (via direct oxygen insertion) or exposed (via hydroxylation/demethylation) in a target scaffold using a P450 monooxygenase and substituted for fluorine using a nucleophilic fluorinating agent. DF: deoxofluorination. (b) Different fluorinated derivatives of a molecule of interest are obtained using P450 variants with different regioselectivities.