Table 3.

Association of rs8034191 and rs1051730 genotypes with lung cancer risk among ever smokers before and after adjustment for age, sex and packyears of cigarette exposure

SNP	Allele	Case	Control	OR (95%CI)	P value	AdjORa (95%CI)	P value
Texas discoveryb
rs8034191	AA	426	493
	AG	536	522	1.19 (1.00–1.42)	5.60 × 10−2	1.18 (0.99–1.42)	0.063
	GG	191	122	1.81 (1.39–2.35)	8.45 × 10−6	1.79 (1.37–2.33)	1.72 × 10−5
rs1051730	GG	424	501
	AG	541	511	1.25 (1.05–1.49)	1.32 × 10−2	1.25 (1.04–1.49)	1.50 × 10−2
	AA	188	125	1.78 (1.37–2.31)	1.52 × 10−5	1.76 (1.35–2.28)	2.85 × 10−5
Texas eplicationb
rs8034191	AA	259	269
	AG	328	253	1.35 (1.06–1.71)	1.37 × 10−2	1.33 (1.04–1.7)	2.50 × 10−2
	GG	111	69	1.67 (1.18–2.36)	3.60 × 10−3	1.68 (1.17–2.42)	5.20 × 10−3
rs1051730	GG	259	266
	AG	330	260	1.30 (1.03–1.65)	2.77 × 10−2	1.31 (1.03–1.69)	3.11 × 10−2
	AA	113	68	1.71 (1.21–2.41)	2.47 × 10−3	1.75 (1.22–2.53)	2.50 ×10−3
UK replicationb
rs8034191	AA	670	448
	AG	858	415	1.38 (1.17–1.63)	1.50 × 10−4	1.31 (1.10–1.56)	2.35 × 10−3
	GG	303	97	2.09 (1.61–2.70)	2.25 × 10−8	1.89 (1.45–2.47)	3.14 × 10−6
rs1051730	GG	687	445
	AG	848	418	1.31 (1.11–1.55)	1.36 × 10−3	1.26 (1.06–1.50)	8.87 ×10−3
	AA	295	93	2.05 (1.58–2.67)	7.02 × 10−8	1.85 (1.41–2.43)	9.10 × 10−6
Pooledc
rs8034191	AA	1,355	1,210
	AG	1,722	1,190	1.29 (1.16–1.44)	2.71 × 10−6	1.28 (1.14–1.43)	1.40 × 10−5
	GG	605	288	1.88 (1.6–2.20)	1.46 × 10−14	1.81 (1.53–2.13)	2.54 × 10−12
rs1051730	GG	1,370	1,212
	AG	1,719	1,189	1.28 (1.15–1.42)	6.49 × 10−6	1.28 (1.15–1.43)	1.10 × 10−5
	AA	596	286	1.84 (1.57–2.17)	8.90 × 10−14	1.80 (1.52–2.13)	4.59 × 10−12

^aSubjects missing packyear information were deleted from these analyses.

^bAdjOdds Ratio column was adjusted for age, sex and packyears.

^cAdjOdds Ratio column was adjusted for age, sex, packyears and centers.