Table 3a. Association of oestrogen receptor α (ER-α) serum bioactivity with risk of breast cancer.
|
Cases
|
||||||||
|---|---|---|---|---|---|---|---|---|
|
ER-α serum bioactivity (pg ml−1)
|
Controls |
All
|
ER-negative
|
ER-positive
|
||||
| Quintilea | Range | N (%) | N (%) | OR (95% CI)b | N (%) | OR (95% CI)b | N (%) | OR (95% CI)b |
| 1st | 0–13.8 | 24 (19.1) | 24 (14.3) | 1.00 (ref.) | 4 (9.5) | 1.00 (ref.) | 20 (15.9) | 1.00 (ref.) |
| 2nd | 13.9–21.6 | 26 (20.8) | 25 (14.9) | 1.00 (0.45–2.23) | 7 (16.7) | 1.53 (0.39–6.06) | 18 (14.3) | 0.92 (0.39–2.18) |
| 3rd | 21.7–29.5 | 25 (20.0) | 23 (13.7) | 0.97 (0.43–2.17) | 12 (28.6) | 3.22 (0.88–11.77) | 11 (8.7) | 0.53 (0.21–1.36) |
| 4th | 29.6–42.0 | 25 (20.0) | 33 (19.6) | 1.24 (0.57–2.71) | 10 (23.8) | 2.18 (0.59–8.11) | 23 (18.3) | 1.09 (0.47–2.52) |
| 5th | ⩾42.1 | 25 (20.0) | 63 (37.5) | 2.47 (1.17–5.20) | 9 (21.4) | 1.84 (0.49–6.89) | 54 (42.9) | 2.70 (1.23–5.90) |
| P-valuec | P=0.008 | P=0.36 | P=0.004 | |||||
a
Quintiles according to distribution among controls.
b
Adjusted for age.
c
P-value for trend, adjusted for age.