Table 4. Associations of urinary phytoestrogen excretion with prostate cancer risk by race/ethnicitya.
|
African Americans
|
Japanese Americans
|
Latinos
|
Whites
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | P for interactionb | |
| Daidzein | |||||||||
| ⩽0.234c | 68/87 | 1.00 | 19/27 | 1.00 | 31/33 | 1.00 | 22/30 | 1.00 | |
| >0.234 | 24/46 | 0.75 (0.39–1.45) | 51/95 | 0.71 (0.35–1.42) | 13/35 | 0.38 (0.16–0.92) | 15/40 | 0.47 (0.19–1.20) | 0.65 |
| Genistein | |||||||||
| ⩽0.067 | 64/91 | 1.00 | 16/26 | 1.00 | 30/37 | 1.00 | 23/31 | 1.00 | |
| >0.067 | 28/42 | 1.28 (0.69–2.38) | 54/96 | 0.92 (0.44–1.95) | 14/31 | 0.52 (0.23–1.21) | 14/39 | 0.42 (0.17–1.06) | 0.34 |
| Equol | |||||||||
| ⩽0.004 | 53/77 | 1.00 | 33/66 | 1.00 | 17/35 | 1.00 | 12/26 | 1.00 | |
| >0.004 | 39/56 | 1.06 (0.53–2.11) | 37/56 | 1.62 (0.80–3.28) | 27/33 | 2.14 (0.76–6.03) | 25/44 | 1.27 (0.48–3.37) | 0.85 |
| Daidzein+Genistein | |||||||||
| ⩽0.326 | 68/90 | 1.00 | 18/24 | 1.00 | 31/32 | 1.00 | 23/31 | 1.00 | |
| >0.326 | 24/43 | 0.84 (0.43–1.64) | 52/98 | 0.63 (0.31–1.29) | 13/36 | 0.37 (0.16–0.87) | 14/39 | 0.41 (0.16–1.10) | 0.54 |
| Daidzein+Genistein | |||||||||
| +Equol | |||||||||
| ⩽0.335 | 68/91 | 1.00 | 18/23 | 1.00 | 31/32 | 1.00 | 21/32 | 1.00 | |
| >0.335 | 24/42 | 0.90 (0.46–1.76) | 52/99 | 0.61 (0.30–1.26) | 13/36 | 0.32 (0.13–0.80) | 16/38 | 0.56 (0.21–1.46) | 0.55 |
| Enterolactone | |||||||||
| ⩽1.091 | 44/63 | 1.00 | 47/72 | 1.00 | 19/35 | 1.00 | 12/23 | 1.00 | |
| >1.091 | 48/70 | 1.02 (0.54–1.94) | 23/50 | 0.67 (0.34–1.31) | 25/33 | 1.76 (0.74–4.19) | 25/47 | 1.17 (0.47–2.92) | 0.33 |
Matching for geographic location (Hawaii or California), race/ethnicity, birth year (±1 year), date (±6 months) and time (±2 h) of specimen collection, and fasting hours (0–<6, 6–<8, 8–<10, and 10+ h). The models were adjusted for age at specimen collection and fasting hours as continuous variables, as well as family history of prostate cancer, BMI, and education.
The P for interaction between urinary phytoestrogen excretion and ethnicity is based on the likelihood ratio test.
Expressed as nmol mg−1 creatinine.