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. 2009 Jun 16;101(1):185–191. doi: 10.1038/sj.bjc.6605137

Table 4. Associations of urinary phytoestrogen excretion with prostate cancer risk by race/ethnicitya.

  African Americans
Japanese Americans
Latinos
Whites
 
  Cases/controls OR (95% CI) Cases/controls OR (95% CI) Cases/controls OR (95% CI) Cases/controls OR (95% CI) P for interactionb
Daidzein                  
 ⩽0.234c 68/87 1.00 19/27 1.00 31/33 1.00 22/30 1.00  
 >0.234 24/46 0.75 (0.39–1.45) 51/95 0.71 (0.35–1.42) 13/35 0.38 (0.16–0.92) 15/40 0.47 (0.19–1.20) 0.65
                   
Genistein                  
 ⩽0.067 64/91 1.00 16/26 1.00 30/37 1.00 23/31 1.00  
 >0.067 28/42 1.28 (0.69–2.38) 54/96 0.92 (0.44–1.95) 14/31 0.52 (0.23–1.21) 14/39 0.42 (0.17–1.06) 0.34
                   
Equol                  
 ⩽0.004 53/77 1.00 33/66 1.00 17/35 1.00 12/26 1.00  
 >0.004 39/56 1.06 (0.53–2.11) 37/56 1.62 (0.80–3.28) 27/33 2.14 (0.76–6.03) 25/44 1.27 (0.48–3.37) 0.85
                   
Daidzein+Genistein                  
 ⩽0.326 68/90 1.00 18/24 1.00 31/32 1.00 23/31 1.00  
 >0.326 24/43 0.84 (0.43–1.64) 52/98 0.63 (0.31–1.29) 13/36 0.37 (0.16–0.87) 14/39 0.41 (0.16–1.10) 0.54
                   
Daidzein+Genistein                  
 +Equol                  
 ⩽0.335 68/91 1.00 18/23 1.00 31/32 1.00 21/32 1.00  
 >0.335 24/42 0.90 (0.46–1.76) 52/99 0.61 (0.30–1.26) 13/36 0.32 (0.13–0.80) 16/38 0.56 (0.21–1.46) 0.55
                   
Enterolactone                  
 ⩽1.091 44/63 1.00 47/72 1.00 19/35 1.00 12/23 1.00  
 >1.091 48/70 1.02 (0.54–1.94) 23/50 0.67 (0.34–1.31) 25/33 1.76 (0.74–4.19) 25/47 1.17 (0.47–2.92) 0.33
a

Matching for geographic location (Hawaii or California), race/ethnicity, birth year (±1 year), date (±6 months) and time (±2 h) of specimen collection, and fasting hours (0–<6, 6–<8, 8–<10, and 10+ h). The models were adjusted for age at specimen collection and fasting hours as continuous variables, as well as family history of prostate cancer, BMI, and education.

b

The P for interaction between urinary phytoestrogen excretion and ethnicity is based on the likelihood ratio test.

c

Expressed as nmol mg−1 creatinine.