Fig. 2.

Domain architecture of RecQ helicase family. RecQ helicases from different organisms are shown. All the members have a conserved helicase domain in the central region of the protein (yellow). The nuclear localization signal (depicted in red) is present at the C-terminus in most of the family members, except in RECQL4 where it resides at the N-terminus. The WRN protein is unique among human RecQ helicase members in having an exonuclease domain (green) at the N-terminus