Figure 1.

Human DTI along rostrocaudal axial segments of the entire cingulate gyrus, spanning from area 32 (segment 1) to area 23 (segment 8). (A) FA values showing a significant region × diagnosis effect in the cingulate white matter, with patients with recent-onset schizophrenia displaying the highest FA in most segments, followed by control subjects and then patients with chronic schizophrenia (ANCOVA F_14,567 = 2.42, p = 0.003). (B) The same pattern was noted in cingulate grey matter, also with a significant region × diagnosis effect (ANCOVA F_14,567 = 3.01, p < 0.001). Vertical bars indicate 95% confidence intervals and values are computed for the age covariate at its mean. Normal controls (n = 38), recent-onset schizophrenia (n = 6), chronic schizophrenia (n = 41); sz, schizophrenia; FA, fractional anisotropy.