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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Mol Immunol. 2009 Jun 6;46(13):2505–2514. doi: 10.1016/j.molimm.2009.05.023

Figure 6.

Figure 6

Protein kinase C (PKC)-dependent migration of secretory granules is a requirement for mtROS-induced histamine release. Mitochondrial dysfunction does not increase β-hexosaminidase secretion from non-sensitized cells and it inhibits release of this enzyme from antigen (Ag)-treated sensitized cells (A). Colchicine (Colh), an inhibitor of the motility of secretory granules, decreases both basal and mtROS-induced release of histamine (B). Chelerythrine chloride (Chel), an inhibitor of PKC, decreases spontaneous and mtROS-induced histamine release (C). A PKC activator, 4 beta-phorbol 12-myristate 13-acetate (PMA), imitates the effects of mtROS (D). Mitochondrial dysfunction was induced by AA treatment (10 μM). ***P< 0.001, ****P< 0.0001.