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. 2009 Jul 29;4(7):e6410. doi: 10.1371/journal.pone.0006410

Figure 7. Four subclusters that are presumably involved in six signaling pathways (indices above protein names are their coordinates in Fig. 7 a).

Figure 7

(a) Cluster for the NF-κB signaling pathway (P<3.2×10−20): TRAF1, TRAF3IP2, TANK, TRPC4AP and RIPK2 are potential pathway members. (b) Cluster for death receptor signaling pathway (P<2.4×10−19): CASP8AP2, DEDD and DEDD2 are potential members in this pathway. (c) Cluster for insulin receptor signaling pathway (P<2.4×10−10): SOCS2, PKD1, PTPN14 are potential pathway members. (d) Cluster for the immune response [T-cell receptor signaling (P<4.9×10−22), B-cell receptor signaling (P<1.1×10−17) and natural killer cell signaling (P<1.7×10−21)]: SRC, PTK2, PTK2B, PTPN12, CRK, CRKL, SIT1, PXN, NEDD9, EVL, KIT and IRS4 are potential members of the above three pathways.