Table 1. Top 10 protein pairs from our 4,233 significant protein pairs.

Protein_A	Protein_B	Ln(P1)	Functional Relationship
SMAD3	SMAD2	−157.6068	SMAD family member
TUBB	TUBB2	−136.0437	Cellular structural activity
PTPN11	PTPN6	−125.8552	Proliferation of cells
BMPR1B	TGFBR1	−124.9466	Differentiation of cells
CALM2	CALM3	−124.9368	Calcium-modulated proteins
MAPK1	MAPK3	−113.0905	MAP kinase family member
CALM1	CALM3	−112.6375	Calcium-modulated proteins
IXL	MED9	−107.7585	Mediator complex
PIK3R1	GRB2	−107.7070	Tyrosine phosphorylation
CALM1	CALM2	−106.1716	Calcium-modulated proteins

All of them share close functional relationships.