Table 2. Activity of PDF-Is on MDR Gram-negative isolates.
| P. aeruginosa | E. aerogenes | K. pneumoniae | |||||||||
| PA01 | 124 | ATCC 13048 | EA5 | EA27 | EA289 | EA298 | EA294 | ATCC 11296 | KP55 | KP63 | |
| Actinonin | 128 | 128 | >128 | 128 | 128 | >128 | 32 | 128 | 128 | 128 | 128/64 |
| Actinonin + PMBN a | 4 | 16 | 8 | 64 | 64 | 32 | 0.5 | 2 | 32 | 32 | 32 |
| SM1 | 128 | 128 | >128 | >128 | >128 | >128 | 64 | 128 | >128 | >128 | 128 |
| SM1 + PMBN a | 2 | 8 | 8 | 32 | 32 | 32 | 8 | 16 | 64 | 64 | 128–64 |
| AB47 | 128 | >128 | >128 | >128 | >128 | 256 | 128 | 128 | 128 | 128 | 128 |
| AB47 + PMBN a | 4 | 8 | 32 | 128 | 128 | 128 | 16 | 32 | 64 | 64 | 64–32 |
| CM | 256 | 256 | 8 | >128 | >128 | >128 | 32 (16) b | 32 | 16 (4) b | 256 | >512 |
| NFX | 2 | 64 | 0,5 | 128 | 128 | 128 | 16 (32) b | 32 | 1 (0.5) b | 16 | 8 |
| CAZ | 8 | 32 | 1 | >512 | >512 | >512 | >512 | >512 | 1 | >512 | >512 |
| ERY | 1024 | 1024 | 512 | 512 | 512 | 512 | 32 | 128 | 128 | 512 | 512 |
| TC | 16 | 64 | 4 | 4 | 16 | 8 | 0.5(0.25) b | 1 | 2 (2) b | >128 | 8 |
Values are means of four independent assays listed in µg/ml.
CM, chloramphenicol; NFX, norfloxacin; CAZ, ceftazidime; ERY, erythromycin; TC, tetracycline.
a
PMBN was used at 1/5 MIC.
b
in bracket the results obtained with 1/5 PMBN are indicated.