Skip to main content
. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: J Immunol. 2009 Apr 1;182(7):4244–4254. doi: 10.4049/jimmunol.0802041

Figure 8. Excessive PD-1 expression on helpless memory cells impairs the recall response.

Figure 8

(A) Helpless VV-specific memory CD8+ T cells were adoptively transferred and challenged, and were treated with R-IgG or anti-PD-1. 5 days post-challenge, expansion of donor-derived VV-specific CD8+ T cells was analyzed as described in Figure 2D. Numbers indicate average fold expansion of VV-specific memory cells for each group. (B) Donor-derived tetramer+ cells at 5 days post-challenge in the experiment described in (A) were stained with Annexin V. Error bars indicate SEM. (C) Effect of anti-PD-1 on recall response of helped VV-specific memory cells. Representative data from two independent experiments, with 4–6 recipient mice per group are shown. Error bars indicate SEM. * p > 0.05, ** p > 0.01.