Table 2.

GO biological processes that are regulated by 5 ng/L EE₂

UPREGULATED
GO ID	GO Biological Process	Fisher p Value	# of Genes Selected	# of Genes on Array
GO:0007275	development	4.35E-03	36	1250
GO:0040036	regulation of fibroblast growth factor receptor signaling	1.58E-02	2	9
GO:0016265	death	1.62E-02	3	27
GO:0018149	peptide cross-linking	1.88E-02	2	10
GO:0050777	negative regulation of immune response	1.88E-02	2	10
GO:0006955	immune response	1.93E-02	10	251
GO:0050776	regulation of immune response	2.09E-02	3	30
GO:0050727	regulation of inflammatory response	2.19E-02	2	11
GO:0006694	steroid biosynthesis	2.26E-02	3	31
GO:0006730	one-carbon compound metabolism	2.44E-02	3	32
GO:0008543	fibroblast growth factor receptor signaling pathway	2.53E-02	2	12
GO:0015758	glucose transport	2.53E-02	2	12
GO:0042770	DNA damage response, signal transduction	2.53E-02	2	12
GO:0008645	hexose transport	2.88E-02	2	13
GO:0015749	monosaccharide transport	2.88E-02	2	13
GO:0008284	positive regulation of cell proliferation	3.24E-02	3	36
GO:0019439	aromatic compound catabolism	3.26E-02	2	14
GO:0007154	cell communication	3.56E-02	41	1692
GO:0043281	regulation of caspase activity	3.65E-02	2	15
GO:0051241	negative regulation of organismal physiological process	3.65E-02	2	15
GO:0009611	response to wounding	3.73E-02	7	167
GO:0009607	response to biotic stimulus	3.91E-02	11	324
GO:0051707	response to other organism	4.03E-02	7	170
GO:0045596	negative regulation of cell differentiation	4.06E-02	2	16
GO:0009605	response to external stimulus	4.18E-02	8	209
GO:0051239	regulation of organismal physiological process	4.19E-02	4	69
GO:0051242	positive regulation of cellular physiological process	4.48E-02	5	103
GO:0006952	defense response	4.48E-02	10	291
GO:0019882	antigen presentation	4.92E-02	2	18
DOWNREGULATED
GO ID	GO Name	Fisher p Value	# of Genes Selected	# of Genes on Array
GO:0006260	DNA replication	9.27E-04	9	124
GO:0009314	response to radiation	1.51E-03	5	40
GO:0006280	mutagenesis	2.08E-03	2	2
GO:0006281	DNA repair	5.33E-03	9	163
GO:0009416	response to light stimulus	5.51E-03	4	34
GO:0006974	response to DNA damage stimulus	7.91E-03	9	174
GO:0006259	DNA metabolism	8.60E-03	17	458
GO:0009719	response to endogenous stimulus	9.05E-03	9	178
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolism	1.29E-02	56	2183
GO:0007623	circadian rhythm	1.74E-02	2	9
GO:0018149	peptide cross-linking	2.07E-02	2	10
GO:0016339	calcium-dependent cell-cell adhesion	2.41E-02	2	11
GO:0006885	regulation of pH	2.78E-02	2	12
GO:0001775	cell activation	3.00E-02	3	33
GO:0045321	immune cell activation	3.00E-02	3	33
GO:0006508	proteolysis	3.17E-02	16	493
GO:0000245	spliceosome assembly	3.17E-02	2	13
GO:0046839	phospholipid dephosphorylation	3.17E-02	2	13
GO:0043283	biopolymer metabolism	3.56E-02	53	2167
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	3.65E-02	5	92
GO:0007156	homophilic cell adhesion	3.94E-02	4	64
GO:0006289	nucleotide-excision repair	4.00E-02	2	15
GO:0009266	response to temperature stimulus	4.00E-02	2	15
GO:0042471	ear morphogenesis	4.00E-02	2	15
GO:0050896	response to stimulus	4.50E-02	26	948
GO:0019941	modification-dependent protein catabolism	4.53E-02	5	98
GO:0043632	modification-dependent macromolecule catabolism	4.53E-02	5	98
GO:0009798	axis specification	4.91E-02	2	17
GO:0030258	lipid modification	4.91E-02	2	17
GO:0042110	T cell activation	4.91E-02	2	17