Figure 2. ERG channels raise AP threshold but have little influence on AP duration.

Bar graphs showing the effects of E-4031 on the firing threshold (A), AP firing frequency on injection of 200 or 600 pA depolarising current (B) and AP half-width on injection of 200 or 600 pA current (C). E-4031 caused a significant increase in neuronal firing and a reduction in firing threshold without altering the AP waveform (Student's unpaired t-test, **P < 0.01).